ACBD3

Protein-coding gene in the species Homo sapiens
ACBD3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2N72

Identifiers
AliasesACBD3, GCP60, GOCAP1, GOLPH1, PAP7, acyl-CoA binding domain containing 3
External IDsOMIM: 606809; MGI: 2181074; HomoloGene: 11227; GeneCards: ACBD3; OMA:ACBD3 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ACBD3
Genomic location for ACBD3
Band1q42.12Start226,144,679 bp[1]
End226,186,741 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ACBD3
Genomic location for ACBD3
Band1 H4|1 84.46 cMStart180,553,608 bp[2]
End180,581,769 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • buccal mucosa cell

  • Epithelium of choroid plexus

  • amniotic fluid

  • gingival epithelium

  • endothelial cell

  • palpebral conjunctiva

  • secondary oocyte

  • cartilage tissue

  • germinal epithelium
Top expressed in
  • secondary oocyte

  • zygote

  • primary oocyte

  • medullary collecting duct

  • aortic valve

  • ascending aorta

  • left colon

  • urothelium

  • belly cord

  • parotid gland
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein kinase A regulatory subunit binding
  • protein binding
  • fatty-acyl-CoA binding
Cellular component
  • integral component of membrane
  • Golgi apparatus
  • membrane
  • mitochondrion
  • Golgi membrane
Biological process
  • steroid biosynthetic process
  • lipid metabolism
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64746

170760

Ensembl

ENSG00000182827

ENSMUSG00000026499

UniProt

Q9H3P7

Q8BMP6

RefSeq (mRNA)

NM_022735

NM_133225

RefSeq (protein)

NP_073572
NP_073572.2

NP_573488

Location (UCSC)Chr 1: 226.14 – 226.19 MbChr 1: 180.55 – 180.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.[5]

Function

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. ACBD3 is involved in maintaining the Golgi structure by interacting with giantin, which affects the transport of protein.[6] The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation.[5]

Interactions

ACBD3 has been shown to interact with GOLGB1.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000182827 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026499 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ACBD3 acyl-Coenzyme A binding domain containing 3".
  6. ^ "ACBD3 - Golgi resident protein GCP60 - Homo sapiens (Human) - ACBD3 gene & protein".
  7. ^ Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (November 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200. PMID 11590181.

External links

Further reading

  • Sohda M, Misumi Y, Yamamoto A, Yano A, Nakamura N, Ikehara Y (2002). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin". J. Biol. Chem. 276 (48): 45298–306. doi:10.1074/jbc.M108961200. PMID 11590181.
  • Li H, Degenhardt B, Tobin D, Yao ZX, Tasken K, Papadopoulos V (2002). "Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated protein". Mol. Endocrinol. 15 (12): 2211–28. doi:10.1210/mend.15.12.0736. PMID 11731621. S2CID 27565320.
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Liu J, Matyakhina L, Han Z, Sandrini F, Bei T, Stratakis CA, Papadopoulos V (2003). "Molecular cloning, chromosomal localization of human peripheral-type benzodiazepine receptor and PKA regulatory subunit type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A mutant cells and tissues". FASEB J. 17 (9): 1189–91. doi:10.1096/fj.02-1066fje. PMID 12692076. S2CID 19079882.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Sbodio JI, Hicks SW, Simon D, Machamer CE (2006). "GCP60 preferentially interacts with a caspase-generated golgin-160 fragment". J. Biol. Chem. 281 (38): 27924–31. doi:10.1074/jbc.M603276200. PMID 16870622.
  • Sbodio JI, Machamer CE (2007). "Identification of a redox-sensitive cysteine in GCP60 that regulates its interaction with golgin-160". J. Biol. Chem. 282 (41): 29874–81. doi:10.1074/jbc.M705794200. PMID 17711851.
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