CAB39

Protein-coding gene in the species Homo sapiens

CAB39

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1UPK, 1UPL, 2WTK, 3GNI, 4FZA, 4FZD, 4FZF, 4NZW, 4O27

Identifiers

Aliases

CAB39, MO25, CGI-66, calcium binding protein 39

External IDs

OMIM: 612174; MGI: 107438; HomoloGene: 69212; GeneCards: CAB39; OMA:CAB39 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q37.1	Start	230,712,842 bp^[1]
Band	2q37.1	End	230,821,075 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 C5	Start	85,721,162 bp^[2]
Band	1\|1 C5	End	85,779,297 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

amniotic fluid

tibia

middle temporal gyrus

Skeletal muscle tissue of rectus abdominis

Skeletal muscle tissue of biceps brachii

mucosa of sigmoid colon

palpebral conjunctiva

glutes

cartilage tissue

triceps brachii muscle

Top expressed in

facial motor nucleus

muscle of thigh

anterior horn of spinal cord

plantaris muscle

transitional epithelium of urinary bladder

soleus muscle

extensor digitorum longus muscle

gastrocnemius muscle

parotid gland

tibialis anterior muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein serine/threonine kinase activator activity protein kinase activator activity protein serine/threonine kinase activity kinase binding protein binding
Cellular component	cytoplasm cytosol serine/threonine protein kinase complex extracellular exosome extracellular region secretory granule lumen ficolin-1-rich granule lumen protein-containing complex
Biological process	intracellular signal transduction protein heterooligomerization signal transduction cellular hypotonic response positive regulation of protein serine/threonine kinase activity negative regulation of potassium ion transmembrane transporter activity positive regulation of peptidyl-threonine phosphorylation peptidyl-serine phosphorylation negative regulation of potassium ion transmembrane transport activation of protein kinase activity neutrophil degranulation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51719


12283

Ensembl


ENSG00000135932


ENSMUSG00000036707

UniProt


Q9Y376


Q06138

RefSeq (mRNA)


NM_001130849 NM_001130850 NM_016289


NM_133781 NM_001355046 NM_001355047

RefSeq (protein)


NP_001124321 NP_001124322 NP_057373


NP_598542 NP_001341975 NP_001341976

Location (UCSC)

Chr 2: 230.71 – 230.82 Mb

Chr 1: 85.72 – 85.78 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.^[5]

The protein encoded by this gene associates with STK11 (Serine/Threonine Kinase 11) and STRAD (STE20-Related ADaptor protein).^[6] CAB39 enhances formation of STK11/STRAD complexes and stimulates STK11 catalytic activity. CAB39 may function as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135932 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036707 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CAB39 calcium binding protein 39".
^ ^a ^b Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR (October 2003). "MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473. PMID 14517248.

External links

Human CAB39 genome location and CAB39 gene details page in the UCSC Genome Browser.

Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity". Trends Cell Biol. 14 (6): 312–9. doi:10.1016/j.tcb.2004.04.001. PMID 15183188.
Hawley SA, Davison M, Woods A, et al. (1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase". J. Biol. Chem. 271 (44): 27879–87. doi:10.1074/jbc.271.44.27879. PMID 8910387.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Boudeau J, Baas AF, Deak M, et al. (2003). "MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473. PMID 14517248.
Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Milburn CC, Boudeau J, Deak M, et al. (2004). "Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor". Nat. Struct. Mol. Biol. 11 (2): 193–200. doi:10.1038/nsmb716. PMID 14730349. S2CID 18401688.
Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Boudeau J, Scott JW, Resta N, et al. (2005). "Analysis of the LKB1-STRAD-MO25 complex". J. Cell Sci. 117 (Pt 26): 6365–75. doi:10.1242/jcs.01571. PMID 15561763.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.