Centalun
Chemical compound
- none
- In general: unscheduled
- 2-methyl-1-phenylbut-3-yne-1,2-diol
- 2033-94-5 Y
- 16252
- 15421 N
- 3N20VGJ39Y
- DTXSID50942486
- Interactive image
- OC(c1ccccc1)C(C#C)(O)C
InChI
- InChI=1S/C11H12O2/c1-3-11(2,13)10(12)9-7-5-4-6-8-9/h1,4-8,10,12-13H,2H3 N
- Key:GQOXDWHRXDPZJK-UHFFFAOYSA-N N
Centalun was developed by Boehringer Ingelheim in 1962[1] and is a psycholeptic drug with hypnotic and sedative effects, via allosteric agonism of the GABAA receptor.[2] It was previously used for sedation in medical procedures such as surgery,[3] orthopedics[4] and gynecology,[5] although it is no longer in clinical use. Despite its history of clinical use, centalun was never incorporated into the CSA and therefore remains unregulated as a drug of abuse.
References
- ^ BE 618130, "Procédé pour l'obtention d'alkinediols"
- ^ Janke W, Glathe H (June 1964). "[Experimental Studies on the Psychic Effect of Sedatives Under Normal and Stress Conditions]". Psychologische Forschung (in German). 27: 377–402. doi:10.1007/bf00421338. PMID 14233519. S2CID 144088161.
- ^ Monecke K (July 1964). "[Pre- and Postoperative Use of Centalun in Surgery]". Deutsches Medizinisches Journal (in German). 15: 470–1. PMID 14238754.
- ^ Bruckschen E (July 1964). "[Sedative Therapy with Centalun in Orthopedics]". Deutsches Medizinisches Journal (in German). 15: 493–4. PMID 14243120.
- ^ Gerlach W, Gerlach E (March 1964). "[Experiences with Centalun in Obstetrical and Gynecological Patients]". Medizinische Monatsschrift (in German). 18: 131–3. PMID 14193290.
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Hypnotics/sedatives (N05C)
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